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Science

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Bacterial Communities and Biofilms

Biofilms are communities of microbes that can be challenging to treat. Pathogenic bacteria like P. aeruginosa and V. cholerae  form biofilms through surface sensing and secondary messenger signals. Understanding these signals can help prevent and treat biofilm infections.
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Immunity and Antimicrobials

  • Innate immunity and antimicrobial peptides
  • Antibiotic-resistant pathogens and antibiotic design
  • Transporter sequences and cell penetrating peptides for drug delivery
  • Budding and scission peptides in viruses
  • Autoimmune diseases (e.g., lupus, psoriasis)
  • COVID-19: molecular mechanisms for acute inflammation; prevention of viral entry and shedding
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Enabling Fundamental Science

  • Protein-lipid interactions and membrane curvature generation (e.g., Apoptosis proteins and cancer therapeutics)
  • Synchrotron x-ray methods
  • Physical chemistry of solvation (e.g., femtosecond hydration dynamics of ions and surfaces)
  • Soft condensed matter physics of self-assembly (e.g., polymers, polyelectrolytes, membranes, liquid crystals, colloids, nanoparticles)

Our Lab

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Photo of Gerard Wong

Gerard Wongorcid-icon

Professor and Principal Investigator

gclwong@seas.ucla.edu

4121E Engineering V

Department of Bioengineering

Department of Chemistry & Biochemistry

California Nanosystems Institute

Members

Wujing Xianorcid-icon

Staff Scientist

wxian@ucla.edu

Haleh Alimohamadiorcid-icon

Calvin Leeorcid-icon

Jaime De Andaorcid-icon

Ph.D. Student

jaime77@ucla.edu

William Schmidtorcid-icon

Ph.D. Student

WSchmidt96@ucla.edu

Wei-Chia Luoorcid-icon

Jonathan Chenorcid-icon

Ph.D. Student

jwhc@ucla.edu

Rena Yangorcid-icon

Ph.D. Student

yangrena@ucla.edu

Julia Zhong

Undergraduate

jjzhong@ucla.edu

Rose Witte

Undergraduate

rewitte@ucla.edu

Yun Su Choi

Undergraduate

yunsu0607@ucla.edu

Summer Perry

Tracy Xue

Undergraduate

txue25@ucla.edu

Alex Fang

Undergraduate

alexfang06@ucla.edu

Brandon Wong

Undergraduate

brw002@ucla.edu

Sanika Deosthali

Winnie Kao

Alumni →

Publications

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  1. How individual P. aeruginosa cells with diverse stator distributions collectively form a heterogeneous macroscopic swarming population

    Jaime de Anda, Sherry L. Kuchma, Shanice S. Webster, Arman Boromand, Kimberley A. Lewis, Calvin K. Lee, Maria Contreras, Victor F. Medeiros Pereira, Deborah A. Hogan, Corey S. O’Hern, George A. O’Toole, Gerard C.L. Wong
    bioRxiv, 2023
    [ paper ] [ pdf ]

  2. Understanding 3D Biomineralization in Human Kidney Stones with Correlative X-Ray Micro-CT & X-Ray Fluorescence Microscopy

    Kymora Scotland, Gerard Wong, Katarzyna Matusik, Michael Lun, Sheraz Gul, Frances Su, David Vine, Jeff Gelb, Wenbing Yun
    Microscopy and Microanalysis, 2022
    [ paper ] [ pdf ]

  3. Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission

    John M. Egner, Kelsey A. Noldenorcid-icon, Megan Cleland Harwig, Ryan P. Bonateorcid-icon, Jaime De Anda, Maxx H. Tessmer, Elizabeth L. Noey, Ugochukwu K. Ihenacho, Ziwen Liuorcid-icon, Francis C. Petersonorcid-icon, Gerard C.L. Wong, Michael E. Widlanskyorcid-icon, R. Blake Hillorcid-icon
    Journal of Biological Chemistry, 2022
    [ paper ] [ pdf ]

  4. Assembly of ordered DNA-curli fibril complexes during Salmonella biofilm formation correlates with strengths of the type I interferon and autoimmune responses

    Lauren K. Nicastro, Jaime de Anda, Neha Jain, Kaitlyn C. M. Grando, Amanda L. Miller, Shingo Bessho, Stefania Gallucci, Gerard C. L. Wong, Çagla Tükelorcid-icon
    PLOS Pathogens, 2022
    [ paper ] [ pdf ]

  5. Amyloid-containing biofilms and autoimmunity

    Amanda L. Miller, Jaime de Anda, Gerard C.L. Wong, Çagla Tükel
    Current Opinion in Structural Biology, 2022
    [ paper ] [ pdf ]

  6. The Power of Touch: Type 4 Pili, the von Willebrand A Domain, and Surface Sensing by Pseudomonas aeruginosa

    Shanice S. Websterorcid-icon, Gerard C. L. Wong, George A. O’Tooleorcid-icon
    Journal of Bacteriology, 2022
    [ paper ] [ pdf ]

  7. Histidine‐Mediated Ion Specific Effects Enable Salt Tolerance of a Pore‐Forming Marine Antimicrobial Peptide

    Wujing Xianorcid-icon, Matthew R. Hennefarthorcid-icon, Michelle W. Leeorcid-icon, Tran Doorcid-icon, Ernest Y. Leeorcid-icon, Anastassia N. Alexandrovaorcid-icon, Gerard C. L. Wongorcid-icon
    Angewandte Chemie International Edition, 2022
    [ paper ] [ pdf ]

  8. Nonmotile Subpopulations of Pseudomonas aeruginosa Repress Flagellar Motility in Motile Cells through a Type IV Pilus- and Pel-Dependent Mechanism

    Kimberley A. Lewis, Danielle M. Vermilyeaorcid-icon, Shanice S. Webster, Christopher J. Geiger, Jaime de Anda, Gerard C. L. Wong, George A. O’Tooleorcid-icon, Deborah A. Hoganorcid-icon
    Journal of Bacteriology, 2022
    [ paper ] [ pdf ]

  9. Force-Induced Changes of PilY1 Drive Surface Sensing by Pseudomonas aeruginosa

    Shanice S. Webster, Marion Mathelié-Guinletorcid-icon, Andreia F. Verissimo, Daniel Schultz, Albertus Viljoenorcid-icon, Calvin K. Leeorcid-icon, William C. Schmidtorcid-icon, Gerard C. L. Wongorcid-icon, Yves F. Dufrêneorcid-icon, George A. O’Tooleorcid-icon
    mBio, 2022
    [ paper ] [ pdf ]

  10. Broadcasting of amplitude- and frequency-modulated c-di-GMP signals facilitates cooperative surface commitment in bacterial lineages

    Calvin K. Leeorcid-icon, William C. Schmidtorcid-icon, Shanice S. Websterorcid-icon, Jonathan W. Chenorcid-icon, George A. O’Toole, Gerard C. L. Wongorcid-icon
    Proceedings of the National Academy of Sciences, 2022
    [ paper ] [ pdf ]

  11. Phenol-Soluble Modulins From Staphylococcus aureus Biofilms Form Complexes With DNA to Drive Autoimmunity

    Kaitlyn Grando, Lauren K. Nicastro, Sarah A. Tursi, Jaime De Anda, Ernest Y. Lee, Gerard C. L. Wong, Çağla Tükel
    Frontiers in Cellular and Infection Microbiology, 2022
    [ paper ] [ pdf ]

  12. Apolipoprotein Mimetic Peptide Inhibits Neutrophil-Driven Inflammatory Damage via Membrane Remodeling and Suppression of Cell Lysis

    Michelle W. Leeorcid-icon, Elizabeth Wei-Chia Luoorcid-icon, Carlos Silvestre-Roig, Yashes Srinivasanorcid-icon, Kiyotaka Akabori, Patricia Lemnitzer, Nathan W. Schmidt, Ghee Hwee Lai, Christian D. Santangelo, Oliver Soehnlein, Gerard C. L. Wongorcid-icon
    ACS Nano, 2021
    [ paper ] [ pdf ]

  13. Silver nanoparticles boost charge-extraction efficiency in Shewanella microbial fuel cells

    Bocheng Caoorcid-icon, Zipeng Zhaoorcid-icon, Lele Pengorcid-icon, Hui-Ying Shiu, Mengning Dingorcid-icon, Frank Songorcid-icon, Xun Guan, Calvin K. Leeorcid-icon, Jin Huang, Dan Zhu, Xiaoyang Fu, Gerard C. L. Wong, Chong Liuorcid-icon, Kenneth Nealsonorcid-icon, Paul S. Weissorcid-icon, Xiangfeng Duanorcid-icon, Yu Huangorcid-icon
    Science, 2021
    [ paper ] [ pdf ]

  14. Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation

    Gerard C L Wongorcid-icon, Jyot D Antaniorcid-icon, Pushkar P Lele, Jing Chen, Beiyan Nanorcid-icon, Marco J Kühn, Alexandre Persat, Jean-Louis Bru, Nina Molin Høyland-Kroghsboorcid-icon, Albert Siryapornorcid-icon, Jacinta C Conradorcid-icon, Francesco Carrara, Yutaka Yawata, Roman Stocker, Yves V Brun, Gregory B Whitfield, Calvin K Leeorcid-icon, Jaime de Anda, William C Schmidt, Ramin Golestanianorcid-icon, George A O’Toole, Kyle A Floyd, Fitnat H Yildiz, Shuai Yang, Fan Jin, Masanori Toyofuku, Leo Eberl, Nobuhiko Nomura, Lori A Zacharoff, Mohamed Y El-Naggar, Sibel Ebru Yalcinorcid-icon, Nikhil S Malvankarorcid-icon, Mauricio D Rojas-Andrade, Allon I Hochbaum, Jing Yan, Howard A Stone, Ned S Wingreen, Bonnie L Bassler, Yilin Wuorcid-icon, Haoran Xu, Knut Drescher, Jörn Dunkel
    Physical Biology, 2021
    [ paper ] [ pdf ]

  15. Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering

    Michael K. Thorsen, Alex Lai, Michelle W. Lee, David P. Hoogerheide, Gerard C. L. Wong, Jack H. Freed, Ekaterina E. Heldweinorcid-icon
    mBio, 2021
    [ paper ] [ pdf ]

  16. Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors

    Nikhil N. Kulkarniorcid-icon, Alan M. O’Neillorcid-icon, Tatsuya Dokoshiorcid-icon, Elizabeth W.C. Luoorcid-icon, Gerard C.L. Wongorcid-icon, Richard L. Galloorcid-icon
    Journal of Biological Chemistry, 2021
    [ paper ] [ pdf ]

  17. Interaction between the type 4 pili machinery and a diguanylate cyclase fine-tune c-di-GMP levels during early biofilm formation

    Shanice S. Websterorcid-icon, Calvin K. Lee, William C. Schmidtorcid-icon, Gerard C. L. Wong, George A. O’Toole
    Proceedings of the National Academy of Sciences, 2021
    [ paper ] [ pdf ]

  18. Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors

    Nikhil N. Kulkarniorcid-icon, Alan M. O’Neillorcid-icon, Tatsuya Dokoshiorcid-icon, Elizabeth W.C. Luoorcid-icon, Gerard C.L. Wongorcid-icon, Richard L. Galloorcid-icon
    Journal of Biological Chemistry, 2021
    [ paper ] [ pdf ]

  19. Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation

    Gerard C L Wongorcid-icon, Jyot D Antaniorcid-icon, Pushkar P Lele, Jing Chen, Beiyan Nanorcid-icon, Marco J Kühn, Alexandre Persat, Jean-Louis Bru, Nina Molin Høyland-Kroghsboorcid-icon, Albert Siryapornorcid-icon, Jacinta C Conradorcid-icon, Francesco Carrara, Yutaka Yawata, Roman Stocker, Yves V Brun, Gregory B Whitfield, Calvin K Leeorcid-icon, Jaime de Anda, William C Schmidt, Ramin Golestanianorcid-icon, George A O’Toole, Kyle A Floyd, Fitnat H Yildiz, Shuai Yang, Fan Jin, Masanori Toyofuku, Leo Eberl, Nobuhiko Nomura, Lori A Zacharoff, Mohamed Y El-Naggar, Sibel Ebru Yalcinorcid-icon, Nikhil S Malvankarorcid-icon, Mauricio D Rojas-Andrade, Allon I Hochbaum, Jing Yan, Howard A Stone, Ned S Wingreen, Bonnie L Bassler, Yilin Wuorcid-icon, Haoran Xu, Knut Drescher, Jörn Dunkel
    Physical Biology, 2021
    [ paper ] [ pdf ]

  20. PACAP is a pathogen-inducible resident antimicrobial neuropeptide affording rapid and contextual molecular host defense of the brain

    Ernest Y. Leeorcid-icon, Liana C. Chanorcid-icon, Huiyuan Wang, Juelline Lieng, Mandy Hung, Yashes Srinivasanorcid-icon, Jennifer Wang, James A. Waschek, Andrew L. Fergusonorcid-icon, Kuo-Fen Leeorcid-icon, Nannette Y. Yountorcid-icon, Michael R. Yeaman, Gerard C. L. Wongorcid-icon
    Proceedings of the National Academy of Sciences, 2020
    [ paper ] [ pdf ]

  21. Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll-Like Receptor 9 Signaling

    Xinhua Chenorcid-icon, Xiaotong Yang, Jaime de Anda, Jun Huang, Dan Li, Hua Xu, Kelsey S. Shields, Mária Džunková, Joshua Hansen, Ishan J. Patel, Eric U. Yee, Douglas T. Golenbock, Marianne A. Grant, Gerard C.L. Wong, Ciarán P. Kelly
    Gastroenterology, 2020
    [ paper ] [ pdf ]

  22. Discovery of Novel Type II Bacteriocins Using a New High-Dimensional Bioinformatic Algorithm

    Nannette Y. Yount, David C. Weaver, Jaime de Anda, Ernest Y. Lee, Michelle W. Lee, Gerard C. L. Wong, Michael R. Yeaman
    Frontiers in Immunology, 2020
    [ paper ] [ pdf ]

  23. Functional Reciprocity of Amyloids and Antimicrobial Peptides: Rethinking the Role of Supramolecular Assembly in Host Defense, Immune Activation, and Inflammation

    Ernest Y. Lee, Yashes Srinivasan, Jaime de Anda, Lauren K. Nicastro, Çagla Tükel, Gerard C. L. Wong
    Frontiers in Immunology, 2020
    [ paper ] [ pdf ]

  24. Selective Promotion of Adhesion of Shewanella oneidensis on Mannose-Decorated Glycopolymer Surfaces

    Thomas D. Youngorcid-icon, Walter T. Liau, Calvin K. Leeorcid-icon, Michael Mellody, Gerard C. L. Wong, Andrea M. Kaskoorcid-icon, Paul S. Weissorcid-icon
    ACS Applied Materials & Interfaces, 2020
    [ paper ] [ pdf ]

  25. Prototypical pacemaker neurons interact with the resident microbiota

    Alexander Klimovichorcid-icon, Stefania Giacomelloorcid-icon, Åsa Björklund, Louis Faureorcid-icon, Marketa Kaucka, Christoph Giezorcid-icon, Andrea P. Murillo-Rincon, Ann-Sophie Matt, Doris Willoweit-Ohlorcid-icon, Gabriele Crupi, Jaime de Andaorcid-icon, Gerard C. L. Wongorcid-icon, Mauro D’Amatoorcid-icon, Igor Adameykoorcid-icon, Thomas C. G. Boschorcid-icon
    Proceedings of the National Academy of Sciences, 2020
    [ paper ] [ pdf ]

  26. Chemokine CCL28 Is a Potent Therapeutic Agent for Oropharyngeal Candidiasis

    Jie He, Monica A. Thomas, Jaime de Anda, Michelle W. Lee, Emma Van Why, Pippa Simpson, Gerard C. L. Wong, Mitchell H. Grayson, Brian F. Volkman, Anna R. Huppler
    Antimicrobial Agents and Chemotherapy, 2020
    [ paper ] [ pdf ]

  27. How do cyclic antibiotics with activity against Gram-negative bacteria permeate membranes? A machine learning informed experimental study

    Michelle W. Lee, Jaime de Anda, Carsten Kroll, Christoph Bieniossek, Kenneth Bradley, Kurt E. Amrein, Gerard C.L. Wong
    Biochimica et Biophysica Acta (BBA) - Biomembranes, 2020
    [ paper ] [ pdf ]

  28. Switchable Membrane Remodeling and Antifungal Defense by Metamorphic Chemokine XCL1

    Acacia F. Dishmanorcid-icon, Michelle W. Leeorcid-icon, Jaime de Andaorcid-icon, Ernest Y. Leeorcid-icon, Jie He, Anna R. Huppler, Gerard C. L. Wong, Brian F. Volkmanorcid-icon
    ACS Infectious Diseases, 2020
    [ paper ] [ pdf ]

  29. c-di-GMP modulates type IV MSHA pilus retraction and surface attachment in Vibrio cholerae

    Kyle A. Floydorcid-icon, Calvin K. Leeorcid-icon, Wujing Xianorcid-icon, Mahmoud Nametalla, Aneesa Valentine, Benjamin Crair, Shiwei Zhu, Hannah Q. Hughesorcid-icon, Jennifer L. Chlebek, Daniel C. Wu, Jin Hwan Parkorcid-icon, Ali M. Farhatorcid-icon, Charles J. Lombaorcid-icon, Courtney K. Ellison, Yves V. Brunorcid-icon, Javier Campos-Gomezorcid-icon, Ankur B. Daliaorcid-icon, Jun Liuorcid-icon, Nicolas Biais, Gerard C. L. Wong, Fitnat H. Yildiz
    Nature Communications, 2020
    [ paper ] [ pdf ]

  30. Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation

    Daniel C. Wuorcid-icon, David Zamorano-Sánchezorcid-icon, Fernando A. Pagliaiorcid-icon, Jin Hwan Parkorcid-icon, Kyle A. Floydorcid-icon, Calvin K. Leeorcid-icon, Giordan Kittsorcid-icon, Christopher B. Roseorcid-icon, Eric M. Bilottaorcid-icon, Gerard C. L. Wong, Fitnat H. Yildizorcid-icon
    PLOS Genetics, 2020
    [ paper ] [ pdf ]

  31. Social Cooperativity of Bacteria during Reversible Surface Attachment in Young Biofilms: a Quantitative Comparison of Pseudomonas aeruginosa PA14 and PAO1

    Calvin K. Leeorcid-icon, Jérémy Vachier, Jaime de Andaorcid-icon, Kun Zhao, Amy E. Baker, Rachel R. Bennett, Catherine R. Armbrusterorcid-icon, Kimberley A. Lewisorcid-icon, Rebecca L. Tarnopol, Charles J. Lombaorcid-icon, Deborah A. Hogan, Matthew R. Parsek, George A. O’Toole, Ramin Golestanian, Gerard C. L. Wong
    mBio, 2020
    [ paper ] [ pdf ]

  32. Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations

    Catherine R Armbrusterorcid-icon, Calvin K Leeorcid-icon, Jessica Parker-Gilham, Jaime de Anda, Aiguo Xia, Kun Zhao, Keiji Murakami, Boo Shan Tsengorcid-icon, Lucas R Hoffman, Fan Jinorcid-icon, Caroline S Harwood, Gerard CL Wong, Matthew R Parsekorcid-icon
    eLife, 2019
    [ paper ] [ pdf ]

  33. Extended Hopanoid Loss Reduces Bacterial Motility and Surface Attachment and Leads to Heterogeneity in Root Nodule Growth Kinetics in a Bradyrhizobium-Aeschynomene Symbiosis

    Brittany J. Belin, Elise M. Tookmanian, Jaime de Anda, Gerard C. L. Wong, Dianne K. Newmanorcid-icon
    Molecular Plant-Microbe Interactions®, 2019
    [ paper ] [ pdf ]

  34. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

    Carlos Silvestre-Roig, Quinte Braster, Kanin Wichapong, Ernest Y. Lee, Jean Marie Teulon, Nihel Berrebeh, Janine Winter, José M. Adrover, Giancarlo Santiago Santos, Alexander Froese, Patricia Lemnitzer, Almudena Ortega-Gómez, Raphael Chevre, Julian Marschner, Ariane Schumski, Carla Winter, Laura Perez-Olivares, Chang Pan, Nicole Paulin, Tom Schoufour, Helene Hartwig, Silvia González-Ramos, Frits Kamp, Remco T. A. Megens, Kerri A. Mowen, Matthias Gunzer, Lars Maegdefessel, Tilman Hackeng, Esther Lutgens, Mat Daemen, Julia von Blume, Hans-Joachim Anders, Viacheslav O. Nikolaev, Jean-Luc Pellequer, Christian Weber, Andrés Hidalgo, Gerry A. F. Nicolaes, Gerard C. L. Wong, Oliver Soehnlein
    Nature, 2019
    [ paper ] [ pdf ]

  35. Functional Specialization in Vibrio cholerae Diguanylate Cyclases: Distinct Modes of Motility Suppression and c-di-GMP Production

    David Zamorano-Sánchez, Wujing Xian, Calvin K. Lee, Mauro Salinas, Wiriya Thongsomboon, Lynette Cegelski, Gerard C. L. Wong, Fitnat H. Yildiz
    mBio, 2019
    [ paper ] [ pdf ]

  36. CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

    Roberto Lande, Ernest Y. Leeorcid-icon, Raffaella Palazzo, Barbara Marinari, Immacolata Pietraforte, Giancarlo Santiago Santos, Yves Mattenberger, Francesca Spadaro, Katia Stefanantoni, Nicoletta Iannace, Aleksandra Maria Dufour, Mario Falchi, Manuela Bianco, Elisabetta Botti, Luca Bianchi, Montserrat Alvarez, Valeria Riccieri, Marie-Elise Truchetet, Gerard C.L. Wong, Carlo Chizzolini, Loredana Frasca
    Nature Communications, 2019
    [ paper ] [ pdf ]

  37. Unifying structural signature of eukaryotic α-helical host defense peptides

    Nannette Y. Yountorcid-icon, David C. Weaver, Ernest Y. Leeorcid-icon, Michelle W. Leeorcid-icon, Huiyuan Wang, Liana C. Chanorcid-icon, Gerard C. L. Wong, Michael R. Yeaman
    Proceedings of the National Academy of Sciences, 2019
    [ paper ] [ pdf ]

  38. Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

    Ernest Y. Leeorcid-icon, Changsheng Zhang, Jeremy Di Domizioorcid-icon, Fan Jinorcid-icon, Will Connell, Mandy Hung, Nicolas Malkoff, Veronica Veksler, Michel Gilliet, Pengyu Renorcid-icon, Gerard C. L. Wong
    Nature Communications, 2019
    [ paper ] [ pdf ]

  39. Modulation of toll-like receptor signaling by antimicrobial peptides

    Ernest Y. Lee, Michelle W. Lee, Gerard C.L. Wong
    Seminars in Cell & Developmental Biology, 2019
    [ paper ] [ pdf ]

  40. Machine learning antimicrobial peptide sequences: Some surprising variations on the theme of amphiphilic assembly

    Michelle W. Lee, Ernest Y. Lee, Andrew L. Ferguson, Gerard C.L. Wong
    Current Opinion in Colloid & Interface Science, 2018
    [ paper ] [ pdf ]

  41. What Can Pleiotropic Proteins in Innate Immunity Teach Us about Bioconjugation and Molecular Design?

    Michelle W. Leeorcid-icon, Ernest Y. Leeorcid-icon, Gerard C. L. Wong
    Bioconjugate Chemistry, 2018
    [ paper ] [ pdf ]

  42. Multigenerational memory and adaptive adhesion in early bacterial biofilm communities

    Calvin K. Leeorcid-icon, Jaime de Andaorcid-icon, Amy E. Baker, Rachel R. Bennett, Yun Luo, Ernest Y. Leeorcid-icon, Joshua A. Keefe, Joshua S. Helali, Jie Ma, Kun Zhao, Ramin Golestanian, George A. O’Tooleorcid-icon, Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2018
    [ paper ] [ pdf ]

  43. Cathelicidin promotes inflammation by enabling binding of self-RNA to cell surface scavenger receptors

    Toshiya Takahashi, Nikhil Nitin Kulkarni, Ernest Y Leeorcid-icon, Ling-juan Zhang, Gerard C. L. Wong, Richard L. Galloorcid-icon
    Scientific Reports, 2018
    [ paper ] [ pdf ]

  44. Applications of Synchrotron-Based Spectroscopic Techniques in Studying Nucleic Acids and Nucleic-Acid-Based Nanomaterials

    Peiwen Wu, Yang Yu, Claire E. McGhee, Li H. Tan, Abhijit Mishra, Gerard Wong, Yi Lu
    Synchrotron Radiation in Materials Science, 2018
    [ paper ] [ pdf ]

  45. Machine learning-enabled discovery and design of membrane-active peptides

    Ernest Y. Lee, Gerard C.L. Wong, Andrew L. Ferguson
    Bioorganic & Medicinal Chemistry, 2018
    [ paper ] [ pdf ]

  46. Molecular Motor Dnm1 Synergistically Induces Membrane Curvature To Facilitate Mitochondrial Fission

    Michelle W. Leeorcid-icon, Ernest Y. Leeorcid-icon, Ghee Hwee Laiorcid-icon, Nolan W. Kennedy, Ammon E. Poseyorcid-icon, Wujing Xianorcid-icon, Andrew L. Fergusonorcid-icon, R. Blake Hillorcid-icon, Gerard C. L. Wong
    ACS Central Science, 2017
    [ paper ] [ pdf ]

  47. Crystallinity of Double-Stranded RNA-Antimicrobial Peptide Complexes Modulates Toll-Like Receptor 3-Mediated Inflammation

    Ernest Y. Leeorcid-icon, Toshiya Takahashi, Tine Curk, Jure Dobnikar, Richard L. Gallo, Gerard C. L. Wong
    ACS Nano, 2017
    [ paper ] [ pdf ]

  48. High-Speed “4D” Computational Microscopy of Bacterial Surface Motility

    Jaime de Andaorcid-icon, Ernest Y. Leeorcid-icon, Calvin K. Leeorcid-icon, Rachel R. Bennett, Xiang Ji, Soheil Soltani, Mark C. Harrison, Amy E. Baker, Yun Luo, Tom Chou, George A. O’Toole, Andrea M. Armaniorcid-icon, Ramin Golestanianorcid-icon, Gerard C. L. Wong
    ACS Nano, 2017
    [ paper ] [ pdf ]

  49. A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity

    Ethan Stolzenberg, Deborah Berry, De Yang, Ernest Y. Lee, Alexander Kroemer, Stuart Kaufman, Gerard C.L. Wong, Joost J. Oppenheim, Supti Sen, Thomas Fishbein, Ad Bax, Brent Harris, Denise Barbut, Michael A. Zasloff
    Journal of Innate Immunity, 2017
    [ paper ] [ pdf ]

  50. What can machine learning do for antimicrobial peptides, and what can antimicrobial peptides do for machine learning?

    Ernest Y. Leeorcid-icon, Michelle W. Leeorcid-icon, Benjamin M. Fulan, Andrew L. Fergusonorcid-icon, Gerard C. L. Wong
    Interface Focus, 2017
    [ paper ] [ pdf ]

  51. Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9

    Sarah A. Tursi, Ernest Y. Leeorcid-icon, Nicole J. Medeirosorcid-icon, Michael H. Lee, Lauren K. Nicastro, Bettina Buttaro, Stefania Gallucciorcid-icon, Ronald Paul Wilson, Gerard C. L. Wong, Çagla Tükelorcid-icon
    PLOS Pathogens, 2017
    [ paper ] [ pdf ]

  52. Designing Hybrid Antibiotic Peptide Conjugates To Cross Bacterial Membranes

    Stephanie Deshayes, Wujing Xian, Nathan W. Schmidt, Shadi Kordbacheh, Juelline Lieng, Jennifer Wang, Sandra Zarmer, Samantha St. Germain, Laura Voyen, Julia Thulin, Gerard C. L. Wong, Andrea M. Kaskoorcid-icon
    Bioconjugate Chemistry, 2017
    [ paper ] [ pdf ]

  53. Interactions between Membranes and “Metaphilic” Polypeptide Architectures with Diverse Side-Chain Populations

    Michelle W. Leeorcid-icon, Ming Han, Guilherme Volpe Bossa, Carly Snell, Ziyuan Song, Haoyu Tang, Lichen Yinorcid-icon, Jianjun Cheng, Sylvio May, Erik Luijtenorcid-icon, Gerard C. L. Wong
    ACS Nano, 2017
    [ paper ] [ pdf ]

  54. Emergence of complex behavior in pili-based motility in early stages of P. aeruginosa surface adaptation

    Yifat Brill-Karniely, Fan Jin, Gerard C. L. Wong, Daan Frenkel, Jure Dobnikar
    Scientific Reports, 2017
    [ paper ] [ pdf ]

  55. Direct Antimicrobial Activity of IFN-β

    Amber Kaplanorcid-icon, Michelle W. Leeorcid-icon, Andrea J. Wolf, Jose J. Limon, Courtney A. Beckerorcid-icon, Minna Dingorcid-icon, Ramachandran Muraliorcid-icon, Ernest Y. Leeorcid-icon, George Y. Liu, Gerard C. L. Wong, David M. Underhillorcid-icon
    The Journal of Immunology, 2017
    [ paper ] [ pdf ]

  56. Multicellular Self-Organization of P. aeruginosa due to Interactions with Secreted Trails

    Anatolij Gelimson, Kun Zhao, Calvin K. Lee, W. Till Kranz, Gerard C. L. Wong, Ramin Golestanian
    Physical Review Letters, 2016
    [ paper ] [ pdf ]

  57. Nanoelectronic Investigation Reveals the Electrochemical Basis of Electrical Conductivity in Shewanella and Geobacter

    Mengning Ding, Hui-Ying Shiu, Shiue-Lin Li, Calvin K. Lee, Gongming Wang, Hao Wu, Nathan O. Weiss, Thomas D. Young, Paul S. Weiss, Gerard C. L. Wong, Kenneth H. Nealson, Yu Huang, Xiangfeng Duan
    ACS Nano, 2016
    [ paper ] [ pdf ]

  58. Evolution of Cell Size Homeostasis and Growth Rate Diversity during Initial Surface Colonization of Shewanella oneidensis

    Calvin K. Lee, Alexander J. Kim, Giancarlo S. Santos, Peter Y. Lai, Stella Y. Lee, David F. Qiao, Jaime De Anda, Thomas D. Young, Yujie Chen, Annette R. Rowe, Kenneth H. Nealson, Paul S. Weiss, Gerard C. L. Wong
    ACS Nano, 2016
    [ paper ] [ pdf ]

  59. Mapping membrane activity in undiscovered peptide sequence space using machine learning

    Ernest Y. Leeorcid-icon, Benjamin M. Fulan, Gerard C. L. Wong, Andrew L. Fergusonorcid-icon
    Proceedings of the National Academy of Sciences, 2016
    [ paper ] [ pdf ]

  60. Effective Dynamics of Microorganisms That Interact with Their Own Trail

    W. Till Kranz, Anatolij Gelimson, Kun Zhao, Gerard C. L. Wong, Ramin Golestanian
    Physical Review Letters, 2016
    [ paper ] [ pdf ]

  61. S100A12 Is Part of the Antimicrobial Network against Mycobacterium leprae in Human Macrophages

    Susan Realegeno, Kindra M. Kelly-Scumpia, Angeline Tilly Dang, Jing Lu, Rosane Teles, Philip T. Liu, Mirjam Schenk, Ernest Y. Leeorcid-icon, Nathan W. Schmidt, Gerard C. L. Wong, Euzenir N. Sarno, Thomas H. Rea, Maria T. Ochoa, Matteo Pellegrini, Robert L. Modlin
    PLOS Pathogens, 2016
    [ paper ] [ pdf ]

  62. Three-dimensional architecture of Vibrio cholera biofilms

    Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2016
    [ paper ] [ pdf ]

  63. How to Teach Old Antibiotics New Tricks

    Stephanie Deshayes, Michelle W. Lee, Nathan W. Schmidt, Wujing Xian, Andrea Kasko, Gerard C. L. Wong
    Host Defense Peptides and Their Potential as Therapeutic Agents, 2016
    [ paper ] [ pdf ]

  64. Sensational biofilms: surface sensing in bacteria

    George A O’Toole, Gerard CL Wong
    Current Opinion in Microbiology, 2016
    [ paper ] [ pdf ]

  65. A review of immune amplification via ligand clustering by self-assembled liquid-crystalline DNA complexes

    Ernest Y. Lee, Calvin K. Lee, Nathan W. Schmidt, Fan Jin, Roberto Lande, Tine Curk, Daan Frenkel, Jure Dobnikarorcid-icon, Michel Gilliet, Gerard C.L. Wong
    Advances in Colloid and Interface Science, 2016
    [ paper ] [ pdf ]

  66. Oxidation of Membrane Curvature-Regulating Phosphatidylethanolamine Lipid Results in Formation of Bilayer and Cubic Structures

    Shalene Sankhagowit, Ernest Y. Lee, Gerard C. L. Wong, Noah Malmstadt
    Langmuir, 2016
    [ paper ] [ pdf ]

  67. Species-dependent hydrodynamics of flagellum-tethered bacteria in early biofilm development

    Rachel R. Bennett, Calvin K. Lee, Jaime De Anda, Kenneth H. Nealson, Fitnat H. Yildiz, George A. O'Toole, Gerard C. L. Wong, Ramin Golestanian
    Journal of The Royal Society Interface, 2016
    [ paper ] [ pdf ]

  68. Interplay between type IV pili activity and exopolysaccharides secretion controls motility patterns in single cells of Myxococcus xanthus

    Wei Hu, Maxsim L. Gibiansky, Jing Wang, Chuandong Wang, Renate Lux, Yuezhong Li, Gerard C. L. Wong, Wenyuan Shi
    Scientific Reports, 2016
    [ paper ] [ pdf ]

  69. Tools for the Microbiome: Nano and Beyond

    Julie S. Biteen, Paul C. Blainey, Zoe G. Cardon, Miyoung Chun, George M. Church, Pieter C. Dorrestein, Scott E. Fraser, Jack A. Gilbert, Janet K. Jansson, Rob Knight, Jeff F. Miller, Aydogan Ozcan, Kimberly A. Prather, Stephen R. Quake, Edward G. Ruby, Pamela A. Silver, Sharif Taha, Ger van den Engh, Paul S. Weiss, Gerard C. L. Wong, Aaron T. Wright, Thomas D. Young
    ACS Nano, 2015
    [ paper ] [ pdf ]

  70. How Bacteria Use Type IV Pili Machinery on Surfaces

    Berenike Maier, Gerard C.L. Wong
    Trends in Microbiology, 2015
    [ paper ] [ pdf ]

  71. Helical antimicrobial polypeptides with radial amphiphilicity

    Menghua Xiong, Michelle W. Leeorcid-icon, Rachael A. Mansbach, Ziyuan Song, Yan Bao, Richard M. Peek, Catherine Yao, Lin-Feng Chen, Andrew L. Fergusonorcid-icon, Gerard C. L. Wong, Jianjun Cheng
    Proceedings of the National Academy of Sciences, 2015
    [ paper ] [ pdf ]

  72. A Dynamic Network Formation Model for Understanding Bacterial Self-Organization Into Micro-Colonies

    Luca Canzian, Kun Zhao, Gerard C. L. Wong, Mihaela van der Schaar
    IEEE Transactions on Molecular, Biological and Multi-Scale Communications, 2015
    [ paper ] [ pdf ]

  73. Viral fusion protein transmembrane domain adopts β-strand structure to facilitate membrane topological changes for virus-cell fusion

    Hongwei Yao, Michelle W. Leeorcid-icon, Alan J. Waring, Gerard C. L. Wong, Mei Hong
    Proceedings of the National Academy of Sciences, 2015
    [ paper ] [ pdf ]

  74. C-di-GMP Regulates Motile to Sessile Transition by Modulating MshA Pili Biogenesis and Near-Surface Motility Behavior in Vibrio cholerae

    Christopher J. Jones, Andrew Utada, Kimberly R. Davis, Wiriya Thongsomboon, David Zamorano Sanchez, Vinita Banakar, Lynette Cegelski, Gerard C. L. Wong, Fitnat H. Yildiz
    PLOS Pathogens, 2015
    [ paper ] [ pdf ]

  75. Liquid-crystalline ordering of antimicrobial peptide-DNA complexes controls TLR9 activation

    Nathan W. Schmidt, Fan Jin, Roberto Lande, Tine Curk, Wujing Xian, Calvin Lee, Loredana Frasca, Daan Frenkel, Jure Dobnikar, Michel Gilliet, Gerard C. L. Wong
    Nature Materials, 2015
    [ paper ] [ pdf ]

  76. Reinventing Cell Penetrating Peptides Using Glycosylated Methionine Sulfonium Ion Sequences

    Jessica R. Kramer, Nathan W. Schmidt, Kristine M. Mayle, Daniel T. Kamei, Gerard C. L. Wong, Timothy J. Deming
    ACS Central Science, 2015
    [ paper ] [ pdf ]

  77. Living in the matrix: assembly and control of Vibrio cholerae biofilms

    Jennifer K. Teschler, David Zamorano-Sánchez, Andrew S. Utada, Christopher J. A. Warner, Gerard C. L. Wong, Roger G. Linington, Fitnat H. Yildiz
    Nature Reviews Microbiology, 2015
    [ paper ] [ pdf ]

  78. Pentobra: A Potent Antibiotic with Multiple Layers of Selective Antimicrobial Mechanisms against Propionibacterium Acnes

    Nathan W. Schmidt, George W. Agak, Stephanie Deshayes, Yang Yu, Alyssa Blacker, Jackson Champer, Wujing Xian, Andrea M. Kasko, Jenny Kim, Gerard C.L. Wong
    Journal of Investigative Dermatology, 2015
    [ paper ] [ pdf ]

  79. A Hierarchical Cascade of Second Messengers Regulates Pseudomonas aeruginosa Surface Behaviors

    Yun Luo, Kun Zhao, Amy E. Baker, Sherry L. Kuchma, Kimberly A. Coggan, Matthew C. Wolfgang, Gerard C. L. Wong, George A. O’Toole
    mBio, 2015
    [ paper ] [ pdf ]

  80. Ternary Nylon-3 Copolymers as Host-Defense Peptide Mimics: Beyond Hydrophobic and Cationic Subunits

    Saswata Chakraborty, Runhui Liu, Zvi Hayouka, Xinyu Chen, Jeffrey Ehrhardt, Qin Lu, Eileen Burke, Yiqing Yang, Bernard Weisblum, Gerard C. L. Wong, Kristyn S. Masters, Samuel H. Gellman
    Journal of the American Chemical Society, 2014
    [ paper ] [ pdf ]

  81. Engineering Persister-Specific Antibiotics with Synergistic Antimicrobial Functions

    Nathan W. Schmidt, Stephanie Deshayes, Sinead Hawker, Alyssa Blacker, Andrea M. Kasko, Gerard C. L. Wong
    ACS Nano, 2014
    [ paper ] [ pdf ]

  82. Vibrio cholerae use pili and flagella synergistically to effect motility switching and conditional surface attachment

    Andrew S. Utada, Rachel R. Bennett, Jiunn C. N. Fong, Maxsim L. Gibiansky, Fitnat H. Yildiz, Ramin Golestanian, Gerard C. L. Wong
    Nature Communications, 2014
    [ paper ] [ pdf ]

  83. Two interdependent mechanisms of antimicrobial activity allow for efficient killing in nylon-3-based polymeric mimics of innate immunity peptides

    Michelle W. Lee, Saswata Chakraborty, Nathan W. Schmidt, Rajan Murgai, Samuel H. Gellman, Gerard C.L. Wong
    Biochimica et Biophysica Acta (BBA) - Biomembranes, 2014
    [ paper ] [ pdf ]

  84. Antimicrobial peptides and induced membrane curvature: Geometry, coordination chemistry, and molecular engineering

    Nathan W. Schmidt, Gerard C.L. Wong
    Current Opinion in Solid State and Materials Science, 2013
    [ paper ] [ pdf ]

  85. Influenza Virus A M2 Protein Generates Negative Gaussian Membrane Curvature Necessary for Budding and Scission

    Nathan W. Schmidt, Abhijit Mishra, Jun Wang, William F. DeGrado, Gerard C. L. Wong
    Journal of the American Chemical Society, 2013
    [ paper ] [ pdf ]

  86. Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms

    Kun Zhao, Boo Shan Tseng, Bernard Beckerman, Fan Jin, Maxsim L. Gibiansky, Joe J. Harrison, Erik Luijten, Matthew R. Parsek, Gerard C. L. Wong
    Nature, 2013
    [ paper ] [ pdf ]

  87. A Critical Evaluation of Random Copolymer Mimesis of Homogeneous Antimicrobial Peptides

    Kan Hu, Nathan W. Schmidt, Rui Zhu, Yunjiang Jiang, Ghee Hwee Lai, Gang Wei, Edmund F. Palermo, Kenichi Kuroda, Gerard C. L. Wong, Lihua Yang
    Macromolecules, 2013
    [ paper ] [ pdf ]

  88. Earthquake-like dynamics in Myxococcus xanthus social motility

    Maxsim L. Gibiansky, Wei Hu, Karin A. Dahmen, Wenyuan Shi, Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2013
    [ paper ] [ pdf ]

  89. Molecular Basis for Nanoscopic Membrane Curvature Generation from Quantum Mechanical Models and Synthetic Transporter Sequences

    Nathan W. Schmidt, Michael Lis, Kun Zhao, Ghee Hwee Lai, Anastassia N. Alexandrova, Gregory N. Tew, Gerard C. L. Wong
    Journal of the American Chemical Society, 2012
    [ paper ] [ pdf ]

  90. Arginine in α-Defensins

    Nathan W. Schmidt, Kenneth P. Tai, Karishma Kamdar, Abhijit Mishra, Ghee Hwee Lai, Kun Zhao, André J. Ouellette, Gerard C.L. Wong
    Journal of Biological Chemistry, 2012
    [ paper ] [ pdf ]

  91. Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide-lipid complexes

    Kun Zhao, Uh-Joo Choe, Daniel T. Kamei, Gerard C. L. Wong
    Soft Matter, 2012
    [ paper ] [ pdf ]

  92. Molecular Solvation Dynamics from Inelastic X-Ray Scattering Measurements

    R. H. Coridan, G. C. L. Wong
    Advances in Chemical Physics, 2012
    [ paper ] [ pdf ]

  93. Dynamics of confined water reconstructed from inelastic x-ray scattering measurements of bulk response functions

    Robert H. Coridan, Nathan W. Schmidt, Ghee Hwee Lai, Peter Abbamonte, Gerard C. L. Wong
    Physical Review E, 2012
    [ paper ] [ pdf ]

  94. Small-Angle X-ray Scattering Studies of Peptide-Lipid Interactions Using the Mouse Paneth Cell α-Defensin Cryptdin-4

    Abhijit Mishra, Kenneth P. Tai, Nathan W. Schmidt, André J. Ouellette, Gerard C.L. Wong
    Methods in Enzymology, 2011
    [ paper ] [ pdf ]

  95. Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal interactions

    Abhijit Mishra, Ghee Hwee Lai, Nathan W. Schmidt, Victor Z. Sun, April R. Rodriguez, Rong Tong, Li Tang, Jianjun Cheng, Timothy J. Deming, Daniel T. Kamei, Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2011
    [ paper ] [ pdf ]

  96. Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential

    Michael Zasloff, A. Paige Adams, Bernard Beckerman, Ann Campbell, Ziying Han, Erik Luijten, Isaura Meza, Justin Julander, Abhijit Mishra, Wei Qu, John M. Taylor, Scott C. Weaver, Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2011
    [ paper ] [ pdf ]

  97. Bacteria use type-IV pili to slingshot on surfaces

    Fan Jin, Jacinta C. Conrad, Maxsim L. Gibiansky, Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2011
    [ paper ] [ pdf ]

  98. All together now: Integrating biofilm research across disciplines

    Gerard C.L. Wong, George A. O’Toole
    MRS Bulletin, 2011
    [ paper ] [ pdf ]

  99. Criterion for Amino Acid Composition of Defensins and Antimicrobial Peptides Based on Geometry of Membrane Destabilization

    Nathan W. Schmidt, Abhijit Mishra, Ghee Hwee Lai, Matthew Davis, Lori K. Sanders, Dat Tran, Angie Garcia, Kenneth P. Tai, Paul B. McCray, André J. Ouellette, Michael E. Selsted, Gerard C. L. Wong
    Journal of the American Chemical Society, 2011
    [ paper ] [ pdf ]

  100. The Pel Polysaccharide Can Serve a Structural and Protective Role in the Biofilm Matrix of Pseudomonas aeruginosa

    Kelly M. Colvin, Vernita D. Gordon, Keiji Murakami, Bradley R. Borlee, Daniel J. Wozniak, Gerard C. L. Wong, Matthew R. Parsek
    PLoS Pathogens, 2011
    [ paper ] [ pdf ]

  101. Flagella and Pili-Mediated Near-Surface Single-Cell Motility Mechanisms in P. aeruginosa

    Jacinta C. Conrad, Maxsim L. Gibiansky, Fan Jin, Vernita D. Gordon, Dominick A. Motto, Margie A. Mathewson, Wiktor G. Stopka, Daria C. Zelasko, Joshua D. Shrout, Gerard C.L. Wong
    Biophysical Journal, 2011
    [ paper ] [ pdf ]

  102. Bacteria Use Type IV Pili to Walk Upright and Detach from Surfaces

    Maxsim L. Gibiansky, Jacinta C. Conrad, Fan Jin, Vernita D. Gordon, Dominick A. Motto, Margie A. Mathewson, Wiktor G. Stopka, Daria C. Zelasko, Joshua D. Shrout, Gerard C. L. Wong
    Science, 2010
    [ paper ] [ pdf ]

  103. Ultrafast Imaging and the Phase Problem for Inelastic X-Ray Scattering

    Peter Abbamonte, Gerard C. L. Wong, David G. Cahill, James P. Reed, Robert H. Coridan, Nathan W. Schmidt, Ghee Hwee Lai, Young Il Joe, Diego Casa
    Advanced Materials, 2010
    [ paper ] [ pdf ]

  104. Electrostatics of Strongly Charged Biological Polymers: Ion-Mediated Interactions and Self-Organization in Nucleic Acids and Proteins

    Gerard C.L. Wong, Lois Pollack
    Annual Review of Physical Chemistry, 2010
    [ paper ] [ pdf ]

  105. Arginine-rich cell-penetrating peptides

    Nathan Schmidt, Abhijit Mishra, Ghee Hwee Lai, Gerard C.L. Wong
    FEBS Letters, 2009
    [ paper ] [ pdf ]

  106. Influence of Salts and Natural Organic Matter on the Stability of Bacteriophage MS2

    Steven E. Mylon, Claudia I. Rinciog, Nathan Schmidt, Leonardo Gutierrez, Gerard C. L. Wong, Thanh H. Nguyen
    Langmuir, 2009
    [ paper ] [ pdf ]

  107. EXAFS studies of catalytic DNA sensors for mercury contamination of water

    B. Ravel, S.C. Slimmer, X. Meng, G.C.L. Wong, Y. Lu
    Radiation Physics and Chemistry, 2009
    [ paper ] [ pdf ]

  108. Hydration Dynamics at Femtosecond Time Scales and Angstrom Length Scales from Inelastic X-Ray Scattering

    Robert H. Coridan, Nathan W. Schmidt, Ghee Hwee Lai, Rahul Godawat, Michael Krisch, Shekhar Garde, Peter Abbamonte, Gerard C. L. Wong
    Physical Review Letters, 2009
    [ paper ] [ pdf ]

  109. Cooperativity and Frustration in Protein-Mediated Parallel Actin Bundles

    Homin Shin, Kirstin R. Purdy Drew, James R. Bartles, Gerard C. L. Wong, Gregory M. Grason
    Physical Review Letters, 2009
    [ paper ] [ pdf ]

  110. Divalent Metal Ion Triggered Activity of a Synthetic Antimicrobial in Cardiolipin Membranes

    Abhigyan Som, Lihua Yang, Gerard C. L. Wong, Gregory N. Tew
    Journal of the American Chemical Society, 2009
    [ paper ] [ pdf ]

  111. Inorganic Mercury Detection and Controlled Release of Chelating Agents from Ion-Responsive Liposomes

    Mehmet Veysel Yigit, Abhijit Mishra, Rong Tong, Jianjun Cheng, Gerard C.L. Wong, Yi Lu
    Chemistry & Biology, 2009
    [ paper ] [ pdf ]

  112. Reversible Cell-Specific Drug Delivery with Aptamer-Functionalized Liposomes

    Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C. L. Wong, Jianjun Cheng, Yi Lu
    Angewandte Chemie International Edition, 2009
    [ paper ] [ pdf ]

  113. Cationic Amphiphiles Increase Activity of Aminoglycoside Antibiotic Tobramycin in the Presence of Airway Polyelectrolytes

    Kirstin R. Purdy Drew, Lori K. Sanders, Zachary W. Culumber, Olena Zribi, Gerard C. L. Wong
    Journal of the American Chemical Society, 2008
    [ paper ] [ pdf ]

  114. Elasticity-mediated nematiclike bacterial organization in model extracellular DNA matrix

    Ivan I. Smalyukh, John Butler, Joshua D. Shrout, Matthew R. Parsek, Gerard C. L. Wong
    Physical Review E, 2008
    [ paper ] [ pdf ]

  115. Self-Organized Gels in DNA/F-Actin Mixtures without Crosslinkers: Networks of Induced Nematic Domains with Tunable Density

    Ghee Hwee Lai, John C. Butler, Olena V. Zribi, Ivan I. Smalyukh, Thomas E. Angelini, Kirstin R. Purdy, Ramin Golestanian, Gerard C. L. Wong
    Physical Review Letters, 2008
    [ paper ] [ pdf ]

  116. Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids

    Lihua Yang, Vernita D. Gordon, Dallas R. Trinkle, Nathan W. Schmidt, Matthew A. Davis, Clarabelle DeVries, Abhigyan Som, John E. Cronan, Gregory N. Tew, Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2008
    [ paper ] [ pdf ]

  117. HIV TAT Forms Pores in Membranes by Inducing Saddle-Splay Curvature: Potential Role of Bidentate Hydrogen Bonding

    Abhijit Mishra, Vernita D. Gordon, Lihua Yang, Robert Coridan, Gerard C. L. Wong
    Angewandte Chemie International Edition, 2008
    [ paper ] [ pdf ]

  118. Control of electrostatic interactions between F-actin and genetically modified lysozyme in aqueous media

    Lori K. Sanders, Wujing Xian, Camilo Guáqueta, Michael J. Strohman, Chuck R. Vrasich, Erik Luijten, Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2007
    [ paper ] [ pdf ]

  119. Synthetic Antimicrobial Oligomers Induce a Composition-Dependent Topological Transition in Membranes

    Lihua Yang, Vernita D. Gordon, Abhijit Mishra, Abhigyan Som, Kirstin R. Purdy, Matthew A. Davis, Gregory N. Tew, Gerard C. L. Wong
    Journal of the American Chemical Society, 2007
    [ paper ] [ pdf ]

  120. Evolution of Growth Modes for Polyelectrolyte Bundles

    Ghee Hwee Lai, Rob Coridan, Olena V. Zribi, Ramin Golestanian, Gerard C. L. Wong
    Physical Review Letters, 2007
    [ paper ] [ pdf ]

  121. Structural Polymorphism of the Actin-Espin System: A Prototypical System of Filaments and Linkers in Stereocilia

    Kirstin R. Purdy, James R. Bartles, Gerard C. L. Wong
    Physical Review Letters, 2007
    [ paper ] [ pdf ]

  122. Temperature Dependence of Thermodiffusion in Aqueous Suspensions of Charged Nanoparticles

    Shawn A. Putnam, David G. Cahill, Gerard C. L. Wong
    Langmuir, 2007
    [ paper ] [ pdf ]

  123. Electrostatics of rigid polyelectrolytes

    Gerard C.L. Wong
    Current Opinion in Colloid & Interface Science, 2006
    [ paper ] [ pdf ]

  124. The Effect of Salt on Self-Assembled Actin-Lysozyme Complexes

    Camilo Guáqueta, Lori K. Sanders, Gerard C.L. Wong, Erik Luijten
    Biophysical Journal, 2006
    [ paper ] [ pdf ]

  125. Counterions between charged polymers exhibit liquid-like organization and dynamics

    Thomas E. Angelini, Ramin Golestanian, Robert H. Coridan, John C. Butler, Alexandre Beraud, Michael Krisch, Harald Sinn, Kenneth S. Schweizer, Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2006
    [ paper ] [ pdf ]

  126. Structure and Dynamics of Liquid Crystalline Pattern Formation in Drying Droplets of DNA

    Ivan I. Smalyukh, Olena V. Zribi, John C. Butler, Oleg D. Lavrentovich, Gerard C. L. Wong
    Physical Review Letters, 2006
    [ paper ] [ pdf ]

  127. Condensation of DNA-actin polyelectrolyte mixtures driven by ions of different valences

    Olena V. Zribi, Hee Kyung, Ramin Golestanian, Tanniemola B. Liverpool, Gerard C. L. Wong
    Physical Review E, 2006
    [ paper ] [ pdf ]

  128. Structure and dynamics of condensed multivalent ions within polyelectrolyte bundles: a combined x-ray diffraction and solid-state NMR study

    Thomas E Angelini, Lori K Sanders, Hongjun Liang, Willy Wriggers, Jay X Tang, Gerard C L Wong
    Journal of Physics: Condensed Matter, 2005
    [ paper ] [ pdf ]

  129. Structure and Stability of Self-Assembled Actin-Lysozyme Complexes in Salty Water

    Lori K. Sanders, Camilo Guáqueta, Thomas E. Angelini, Jae-Wook Lee, Scott C. Slimmer, Erik Luijten, Gerard C. L. Wong
    Physical Review Letters, 2005
    [ paper ] [ pdf ]

  130. Polymorphism of DNA-anionic liposome complexes reveals hierarchy of ion-mediated interactions

    Hongjun Liang, Daniel Harries, Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2005
    [ paper ] [ pdf ]

  131. Direct observation of counterion organization in F-actin polyelectrolyte bundles

    T. E. Angelini, H. Liang, W. Wriggers, G. C. L. Wong
    The European Physical Journal E, 2005
    [ paper ] [ pdf ]

  132. Salt-induced condensation in actin-DNA mixtures

    O. V Zribi, H Kyung, R Golestanian, T. B Liverpool, G. C. L Wong
    Europhysics Letters (EPL), 2005
    [ paper ] [ pdf ]

  133. Roles of Anionic and Cationic Template Components in Biomineralization of CdS Nanorods Using Self-Assembled DNA−Membrane Complexes

    Hongjun Liang, Thomas E. Angelini, Paul V. Braun, Gerard C. L. Wong
    Journal of the American Chemical Society, 2004
    [ paper ] [ pdf ]

  134. The Soft Sector in Physics

    Gerard C. L. Wong
    Science, 2004
    [ paper ] [ pdf ]

  135. Self-assembled virus-membrane complexes

    Lihua Yang, Hongjun Liang, Thomas E. Angelini, John Butler, Robert Coridan, Jay X. Tang, Gerard C. L. Wong
    Nature Materials, 2004
    [ paper ] [ pdf ]

  136. Molecular Imprinting of Biomineralized CdS Nanostructures:  Crystallographic Control Using Self-Assembled DNA−Membrane Templates

    Hongjun Liang, Thomas E. Angelini, James Ho, Paul V. Braun, Gerard C. L. Wong
    Journal of the American Chemical Society, 2003
    [ paper ] [ pdf ]

  137. Like-charge attraction between polyelectrolytes induced by counterion charge density waves

    Thomas E. Angelini, Hongjun Liang, Willy Wriggers, Gerard C. L. Wong
    Proceedings of the National Academy of Sciences, 2003
    [ paper ] [ pdf ]

  138. Ion Multivalence and Like-Charge Polyelectrolyte Attraction

    John C. Butler, Thomas Angelini, Jay X. Tang, Gerard C. L. Wong
    Physical Review Letters, 2003
    [ paper ] [ pdf ]

  139. Lamellar Phase of Stacked Two-Dimensional Rafts of Actin Filaments

    Gerard C. L. Wong, Alison Lin, Jay X. Tang, Youli Li, Paul A. Janmey, Cyrus R. Safinya
    Physical Review Letters, 2003
    [ paper ] [ pdf ]

  140. Controlled Modification of Microstructured Silicon Surfaces for Confinement of Biological Macromolecules and Liquid Crystals

    T. Pfohl, J. H. Kim, M. Yasa, H. P. Miller, G. C. L. Wong, F. Bringezu, Z. Wen, L. Wilson, M. W. Kim, Y. Li, C. R. Safinya
    Langmuir, 2001
    [ paper ] [ pdf ]

  141. Characterizing the hard x-ray diffraction properties of a GaAs linear Bragg-Fresnel lens

    Youli Li, Gerard C. L. Wong, Ryan Case, Cyrus R. Safinya, Ernie Caine, Evelyn Hu, Partricia Fernandez
    Applied Physics Letters, 2000
    [ paper ] [ pdf ]

  142. Hierarchical Self-Assembly of F-Actin and Cationic Lipid Complexes: Stacked Three-Layer Tubule Networks

    Gerard C. L. Wong, Jay X. Tang, Alison Lin, Youli Li, Paul A. Janmey, Cyrus R. Safinya
    Science, 2000
    [ paper ] [ pdf ]

  143. Mesoscopic structure of DNA-membrane self-assemblies: Microdiffraction and manipulation on lithographic substrates

    Gerard C. L. Wong, Youli Li, Ilya Koltover, Cyrus R. Safinya, Zhonghou Cai, Wenbing Yun
    Applied Physics Letters, 1998
    [ paper ] [ pdf ]

  144. Structural Studies of DNA-Cationic Lipid Complexes Confined in Lithographically Patterned Microchannel Arrays

    Y. Li, G. C. L. Wong, E. Caine, E. L. Hu, C. R. Safinya
    International Journal of Thermophysics, 1998
    [ paper ] [ pdf ]

  145. Bragg-Fresnel optics for hard x-ray microscopy: Development of fabrication process and x-ray characterization at the Advanced Photon Source

    Youli Li, Gerard C. L. Wong, Cyrus R. Safinya, Ernie Caine, Evelyn L. Hu, Dean Haeffner, Patricia Fernandez, Wenbing Yun
    Review of Scientific Instruments, 1998
    [ paper ] [ pdf ]

  146. Thinning transitions and fluctuations of freely suspended smectic-A films as studied by specular and diffuse X-ray scattering

    E.A.L. Mol, G.C.L. Wong, J.M. Petit, F. Rieutord, W.H. de Jeu
    Physica B: Condensed Matter, 1998
    [ paper ] [ pdf ]

  147. Induced long-range order in crosslinked 'one-dimensional' stacks of fluid monolayers

    Gerald C. L. Wong, Wim H. de Jeu, Henry Shao, Keng S. Liang, Rudolf Zentel
    Nature, 1997
    [ paper ] [ pdf ]

  148. Critical examination of prewetting and surface melting on caprolactam

    Gerard C. L. Wong, Wim H. de Jeu, Gertjan Bögels, Erwin P. G. van den Berg, Piet Bennema
    Physical Review B, 1997
    [ paper ] [ pdf ]

  149. Thermal Fluctuations of Freely Suspended Smectic-A Films from Mesoscopic to Molecular Length Scales

    E. A. L. Mol, G. C. L. Wong, J. M. Petit, F. Rieutord, W. H. de Jeu
    Physical Review Letters, 1997
    [ paper ] [ pdf ]

  150. Orientational Wetting in Hybrid Liquid Crystalline Block Copolymers

    Gerard C. L. Wong, Jan Commandeur, Hartmut Fischer, Wim H. de Jeu
    Physical Review Letters, 1996
    [ paper ] [ pdf ]

  151. Parallel Adatom Chains on Si(111): A Chemisorption-Induced Surface Reconstruction

    G. C. L. Wong, C. A. Lucas, D. Loretto, A. P. Payne, P. H. Fuoss
    Physical Review Letters, 1994
    [ paper ] [ pdf ]

  152. Direct observation of interface and surface steps in epitaxial films by dark-field transmission electron microscopy

    D. Loretto, F. M. Ross, C. A. Lucas, G. C. L. Wong
    Applied Physics Letters, 1994
    [ paper ] [ pdf ]

  153. Epitaxial growth mechanisms and structure of CaF2-Si(111)

    C. A. Lucas, D. Loretto, G. C. L. Wong
    Physical Review B, 1994
    [ paper ] [ pdf ]

  154. Structural transitions of the CaF2-Si(111) interface

    C. A. Lucas, G. C. L. Wong, D. Loretto
    Physical Review Letters, 1993
    [ paper ] [ pdf ]

  155. CaF2-Si(111) as a model ionic-covalent system: Transition from chemisorption to epitaxy

    G. C. L. Wong, D. Loretto, Eli Rotenberg, Marjorie A. Olmstead, C. A. Lucas
    Physical Review B, 1993
    [ paper ] [ pdf ]

  156. Initial stages in the epitaxial growth of NaCl on Ge(001)

    C.A. Lucas, G.C.L. Wong, C.S. Dower, F.J. Lamelas, P.H. Fuoss
    Surface Science, 1993
    [ paper ] [ pdf ]

  157. Order-disorderc(4×2)-(2×1) transition on Ge(001): Anin situx-ray scattering study

    C. A. Lucas, C. S. Dower, D. F. McMorrow, G. C. L. Wong, F. J. Lamelas, P. H. Fuoss
    Physical Review B, 1993
    [ paper ] [ pdf ]

  158. Solid state amorphization reactions in deformed Ni-Zr multilayered composites

    G. C. Wong, W. L. Johnson, E. J. Cotts
    Journal of Materials Research, 1990
    [ paper ] [ pdf ]

  159. Calorimetric observations of amorphous and crystalline Ni-Zr alloy formation by solid-state reaction

    E. J. Cotts, G. C. Wong, W. L. Johnson
    Physical Review B, 1988
    [ paper ] [ pdf ]