Innate immune peptides play an essential role in the immune system's defense mechanism. These peptides can chaperone and organize Toll Like Receptor (TLR) ligands into crystalline complexes. These complexes are highly organized, with multivalent presentation at spacings that match the steric size of TLRs. This leads to amplified immune activation, which helps the immune system to fight against infections. For instance, in plasmacytoid dendritic cells, dsDNA-TLR9 complexes are formed, and in keratinocytes, dsRNA-TLR3 complexes are formed. These complexes have been found to activate the immune system effectively. Once the immune system is activated, it can recognize and destroy pathogens, including viruses and bacteria.
Moreover, the manner in which these innate immune peptides interact with their ligands can be likened to a programatic assembly of supramolecular complexes that can be either pro-inflammatory or anti-inflammatory. The ability to assemble these complexes is an essential feature of the immune system, as it allows the immune system to respond appropriately to different types of infections.
More general references for our work on immunity and antimicrobials are listed below. The papers are available on our publications page.
- Kulkarni et al, J. Biol. Chem, 2021
- Chen, Yang, de Anda et al, Gastroenterology, 2020
- Lee et al, Frontiers in Immunology, 2020
- Lee et al, Nature Comm, 2019
- Lande et al, Nature Comm 2019
- Takahashi et al, Scientific Reports, 2018
- Lee et al, Curr Opinion in Colloid & Interface Science, 2018
- Lee et al, ACS Nano, 2017
- Stolzenberg et al, J Innate Immunol, 2017
- Lee et al, Advances in Colloids & Interface Science, 2016
- Schmidt et al, Nature Materials, 2015