Membrane Destabiliation Title

We are interested in a broad range of topics in this area. One general topic is peptide or protein induced membrane remodeling. This includes antimicrobial peptides (AMPs) from innate immunity, which can permeate prokaryotic membranes selectively but not eukaryotic membranes, so that they kill bacterial cells but not mammalian cells. It also includes cell penetrating peptides (CPPs) like HIV Tat, which can transiently permeate cell membranes and deliver cargo like therapeutic molecules (ex: drugs, siRNA, etc) but without permanent damage. This is especially important for efficient and non-cytotoxic drug delivery. Another example is the Bcl2 proteins, which orchestrate cell death events in the intrinsic apoptosis pathway, by making holes in mitochondria in a highly regulated manner. (Too little apoptosis leads to cancer; too much leads to degenerative diseases.) Another topic is the role of Toll-Like Receptors (TLR) in autoimmune diseases such as lupus and psoriasis.

There is too much to describe in detail, but here is some of our recent work with links to the original papers.

How does the M2 protein of the Influenza A virus bend membranes to produce budding and scission?

How do different hydrogen bonding schemes between different amino acids and lipid headgroups generate nanoscopic membrane curvature needed for pore formation?

Nature’s design principles for antimicrobial peptides (AMPs)

Cell Penetrating Peptides (CPPs) work like Swiss Army knife

Antivirals inspired by the shark’s immune system

More general references for our work on immunity and antimicrobials are listed below. The papers are available on our publications page.

  • Schmidt et al, ACS Nano 2014 (Editors’ Choice)
  • Lee et al, BBA 2014
  • Schmidt et al., JACS 2013
  • Schmidt et al, Current Opinion in Solid State & Materials Science, 2013
  • Hu et al, Macromol, 2013
  • Schmidt et al., JACS 2012
  • Zhao et al, Soft Matter 2012
  • Schmidt et al., J Biol Chem 2012
  • Zasloff et al, PNAS 2011c
  • Mishra et al, PNAS 2011b
  • Schmidt et al., JACS 2011
  • Mishra et al., Methods in Enzymology 2011
  • Schmidt et al, FEBS Lett 2010
  • Som et al, JACS 2009
  • Purdy et al, JACS 2009
  • Cao et al, Angew Chem 2009
  • Yang et al, PNAS 2008
  • Mishra et al, Angew Chem 2008
  • Yang et al, JACS 2007

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