CDC Covid-19
Image from CDC Library

In a collaboration between multiple institutions, we are conducting research that aims to understand

(1) why the coronavirus responsible for COVID-19 is so hyperinfectious, and

(2) why it induces so much inflammation, which is one of the principal reasons for its lethality.

Based on our machine learning aided analysis, we are testing methods to inhibit both infection and inflammation.

Our previous antiviral works include:

How viral fusion proteins work (2015 PNAS, Yao, Lee, et al)

How the influenza virus buds out of membranes (2013 JACS, Schmidt, Mishra, et al)

What can we learn from the shark’s antiviral defense? (2011 PNAS, Zasloff, Adams, et al)

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